49ers odds from Caesars Sportsbook, while the over-under for total points scored is 45.5. Los Angeles is a 3.5-point favorite in the latest Rams vs. Kickoff from SoFi Stadium is set for 6:30 p.m. The Rams also are hoping to halt their six-game losing streak in the all-time series by defeating the 49ers for the first time since the 2018 regular-season finale. Los Angeles (14-5) looks to avenge that defeat when it hosts San Francisco (12-7) in the 2022 NFC Championship Game on Sunday. Their last loss in a conference title game came in 1989, their only postseason meeting with the San Francisco 49ers.
The Los Angeles Rams have gone 4-6 in NFC Championship Games but have been victorious in each of their last three appearances.
